Allylic and benzylic sp3 C-H oxidation in water.
نویسندگان
چکیده
A copper-catalyzed method for the oxidation of allylic and benzylic sp(3) C-H by aqueous tert-butyl hydroperoxide (T-Hydro) in water using a recyclable fluorous ligand has been developed. The reaction procedure is tolerant to additional functional groups and the fluorous ligand could be reused with little loss of catalytic activity.
منابع مشابه
Metal-free direct alkylation of unfunctionalized allylic/benzylic sp3 C–H bonds via photoredox induced radical cation deprotonation† †Electronic supplementary information (ESI) available: Experimental procedures, characterization data and NMR spectra of all new compounds; ORTEP drawing of compound 41 (major diastereomer). CCDC 1506724. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7sc00953d Click here for additional data file. Click here for additional data file.
Despite notable recent efforts, a catalytic and convenient strategy for the direct alkylation of unactivated allylic or benzylic sp C–H bonds remains a formidable challenge facing the synthesis community. We herein report an unprecedented allylic/benzylic alkylation using only an organo-photoredox catalyst, which enables coupling of a broad scope of alkenes/arenes and electron-deficient alkenes...
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 13 4 شماره
صفحات -
تاریخ انتشار 2015